85-1483-87　2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907) 10mg　CAS No:313516-66-4　C5029-18

特徴

• A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
• Alternate Names:T0070907
• Molecular Weight:277.66
• Appearance:Supplied as a light orange solid.
• Molecular Formula:C₁₂H₈ClN₃O₃
• Solubility:DMSO (Slightly), Methanol (Slightly)
• Melting Point:>184°C (dec.)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.