85-1470-21　Azidothymidine (3'-Azido-3'-deoxythymidine, AZT, Zidovudine) 1g　CAS No:30516-87-1　A5014

特徴

• Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3nM) with low cytotoxicity (CC₅₀ >5uM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.
• Synonyms:AZT; Zidovudine; Retrovis; Timazid; Retrovir; NSC 602670
• Molecular Formula:C10H13N5O4
• Molecular Weight:267.24
• Appearance:Supplied as a white to off-white crystalline solid.
• Purity:97.0-102.0% (HPLC)
• Melting Point:118-120°C
• Solubility:Methanol, DMSO
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.