Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer.
Molecular Weight:551.64
Molecular Formula:C34H29N7O
Melting Point:256-258ºC
Solubility:DMSO, Methanol (sparingly)
Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:SiO2; Dichloromethane: Methanol: NH4OH; 9:1:0.1; Visualized with UV and AMCS; SIngle spot. Rf=0.6
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
