Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo.
Method for Determining Identitiy:H NMR Spectroscopic Analysis
TLC Conditions:SiO2; Hexane: Ethyl Acetate; 2:1; Visualized with AMCS; Single Spot; Rf=0.25.
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
