85-1460-45　Teriflunomide (Leflunomide EP Impurity B) 1g　CAS No:163451-81-8　A0001-67

特徴

• Teriflunomide (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a..
• Synonyms:N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide; Leflunomide EP Impurity B; Aubagio; A1726; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix; HMR 1726; SU 20
• Molecular Formula:C12H9F3N2O2
• Molecular Weight:270.21
• Appearance:White solid
• Purity:≥95%
• Melting Point:222-232ºC
• Solubility:DMSO (Slightly), Methanol (Sparingly)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.