Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is a 130aa long peptide with a putative 33aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors- -G-protein coupled receptors (GPCRs) OX1R and OX2R.
Source:Mouse/rat/human Orexin-A is a 33aa peptide. Full length Orexin-A peptide corresponding to aa1-33 (
Activity:Full length Orexin-A has been shown to be biologically active.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：1mg
Grade：Highly Purified
Purity：Purified by HPLC
Form：Supplied as a lyophilized powder with no additives. Reconstitute with 1ml ddH2O and mix for 15 minutes at RT.
