BMPs are important regulators of key events in the processes of bone formation during embryogenesis, postnatal growth, remodeling and regeneration of the skeleton. The BMPs function by binding to a receptor complex that is found on all normal cells and is composed of type-I and –II receptors. The primary unit of bone formation is osteoblast, the bone forming cell. These osteoblast cells respond to physical loading by transducing signals that alter gene expression patterns. Cbfa (core binding factor), the osteoblast specific transcription factor plays an important role in osteoblast differentiation and function
Cbfa1 / Runx2 / OSF2 (alternatively spliced form 507aa and 522aa in human (chr 6p21) and 528aa or 596aa in mouse) is expressed in bone thymus, testis but not in brain, lung, heart or kidney. It is a transcription factor involved in osteoblastic differentiation and skeletal morphogenesis, essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. Defects in Cbfa1 are the cause of cleidocranial dysplasia (CCD), an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation.
Source:15aa peptide from mouse CBFA1.
Epitope Location:~Mid-region
Species Sequence Homology:Human, rat-100%; Chicken-93%.
Applications:Suitable for use in ELISA. Other applications not tested.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：100ug
Source Antigen：Mouse synthetic peptide
Grade：Purified
Purity：Purified
Form：Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
