85-1454-69　Rottlerin 50mg　R3005-01

特徴

• Rottlerin is an inhibitor of PRAK (IC50 1.9M), MAPKAP Kinase 2 (IC50 5.4M) and CaM Kinase III (3-6M). Rottlerin inhibits PMA-induced edema in mouse ear. For use as an Inhibitor of PRAK, MAPKAP kinase 2, and CaM Kinase III activity. Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
• Synonyms:(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;3’-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2’,4’,6’-trihydroxy-5’-methyl-acetophenone; (2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; Mallotoxin; NSC 56346; NSC 94525
• Molecular Formula:C30H28O8
• Molecular Weight:516.54
• Appearance:Orange-brown powder.
• Purity:≥95%
• Melting Point:200-205°C(lit.)
• Solubility:Soluble in DMSO, chloroform or 100% ethanol. Not soluble in water.
• Warning!Toxic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure.
• Storage and Stability:Powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO, chloroform, or 100% ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.