85-1452-55　［取扱停止］Prouroguanylin, Recombinant, Human 10ug　P9119-90

特徴

• Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen. Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leasing to elevated blood pressure independent of the level of diatary salt intake. Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.
• Description:The Recombinant Human Prouroguanylin is 10kD protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues.
• Amino Acid Sequence:GPVYIQYQGF RVQLESMKKL SDLEAQWAPS PRLQAQSLLP AVCHHPALPQ DLQPVCASQE ASSIFKTLRT IANDDCELCV NVACTGCL
• Specificity:The recombinant sequnce is 100% homologous to the native human sequence.
• Applications:Western blotting, ELISA
• Reconstitution:Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
• Stability/Shelf Life:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated thaw-freeze cycles and store at -80°C. Reconstituted protein can be stored at 4°C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20°C.