85-1450-16　［取扱停止］Glucagon Like Peptide 1 (7-36), amide (human) (GLP1) 1mg　G2040-13P

特徴

• GLP-1 is a incretion hormone, which has been shown to stimulate secretion of insulin in the presence of elevated blood glucose concentrations, but not during periods of low blood glucose concentrations (hypoglycemia). GLP-1 is released from gut endocrine cells in response to nutrient ingestion. The hormone is a physiologic mediator of satiety and regulates energy absorption and disposal. GLP-1 is an insulinotropic hormone that has the ability to render pancreatic beta cells glucose-competent. It has been used in the therapy of type-2 diabetes. GLP-1 has cytokine activity, although it is not classified as such due its small size GLP-1 enhances cell differentiation, plays a role in tissue regeneration, and mediates cytoprotection.
• Description:GLP-1 is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecular mass of 3.29kD. GLP-1 is a incretion hormone, which has been shown to stimulate secretion of insulin in the presence of elevated blood glucose concentrations, but not during periods of low blood glucose concentrations (hypoglycemia). GLP-1 is released from gut endocrine cells in response to nutrient ingestion. The hormone is a physiologic mediator of satiety and regulates energy absorption and disposal. GLP-1 is an insulinotropic hormone that has the ability to render pancreatic beta cells glucose-competent. It has been used in the therapy of type-2 diabetes. GLP-1 has activities of cyokines, although it is not classified as such due its small size GLP-1 enhances cell differentiation, plays a role in tissue regeneration, and mediates cytoprotection. GLP-1 is purified by proprietary chromatographic techniques.
• Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be His-Ala-Glu-Gly-Thr.
• Biological Activity:1. Regulates Glucose levels rapidly2. Reduces Insulin resistence3. Reduces Glucagon4. Reduces HbA1c5. Stimulates beta cell grwoth which stimulates insulin production.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O to ≥0.1mg/ml. Add a carrier protein (0.1% HSA or BSA) for long term storage. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.