85-1449-82　［取扱停止］Exendin 4, Recombinant 100ug　E9050-03R

特徴

• Recombinant Exendin-4 is a glucagon like peptide-1 receptor agonist. The native hormone is produced in the gut of Gila monster Heloderma suspectrum (a type of reptile found in the desert) that stimulates insulin production without causing threateningly low blood sugar, which can occur after using insulin and some anti-diabetes products. Recently, researchers used extracted saliva from gila monsters to create an unprecedented breakthrough in Diabetes Type 2 treatment. Exedin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion and slows gastric emptying in vivo. It also promotes B-cell proliferation and neogenesis in vitro and in animal models. Exedin-4 stimulates an increase in acinar cAMP, without stimulating the release of amylase.
• Recombinant Exendin-4 is a novel 39-amino acids peptide having a molecular mass of 4186.7 dalton, which shares 53%, sequence homology with GLP-17-36 amide and interacts with the same membrane receptor.
• Amino Acid Sequence:The sequence was determined and was found to be: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser.
• Biological Activity:1. Regulates Glucose levels rapidly
• 2. Reduces Insulin resistance. 3. Reduces Glucagon
• 4. Reduces HbA1c
• 5. Stimulates beta cell growth which stimulates insulin production.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O to ≥0.1mg/ml. Add a carrier protein (0.1% HSA or BSA) for long term storage. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.