EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, 02, 03, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF- ), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
This recombinant human EGFR comprises amino acids 672-1210 of human EGFR (Accession #P00533), fused with a GST-tag at the N-terminus with thrombin cleavage sites and has a MW of 89.171kD.
Applications:Suitable for use in ELISA, Inhibition Assays and Western Blot. Other applications not tested.
Specific Activity:30pmol/ug x min
Storage and Stability:Store -20°C to -70°C. Stable for 12 months. Please avoid freeze-thaw cycles.
仕様
Size：5ug
Source Antigen：Recombinant, Sf9 insect cells
Grade：Purified
Purity：Purified.
Form：Supplied as a sterile-filtered liquid in 50mM HEPES, pH 7.5, 100mM sodium chloride, 5mM DTT, 15mM reduced glutathione and 20% glycerol.
