85-1449-16　［取扱停止］Collapsin Response Mediator Protein 1, Recombinant, Human (CRMP1, Dihydropyrimidinase-like 1, DPYSL1, DRP1, ULIP3, CRAM) 5ug　C7517-05

特徴

• Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The X-ray crystal structure of murine CRMP1 was determined at 2.1 resolution and demonstrates that CRMP1 is a bilobed 'lung-shaped' protein forming a tetrameric assembly.
• Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
• Applications: Suitable for use in ELISA, Inhibition Assays, Western Blotting.
• Stability:Store vial at -20-80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.