85-1447-83　［取扱停止］Aminoacylase 1 (ACY1) Recombinant, Human 10ug　A1374-05C

特徴

• Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.
• Description:Recombinant Human ACY-1 produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids 1-408 and having a total molecular mass of 46.9kD. Recombinant Human ACY1 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques.
• Applications:
• ELISA • MS • Inhibition Assays • Western Blotting
• Stability:Recombinant ACY-1 although stable at 140C for 1 week, should be stored desiccated below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.