85-1440-30　［取扱停止］MAGE 1, Recombinant, Human (Antigen MZ2-E, MAGE1A, MAGEA1, Melanoma Antigen 1, Melanoma Associated Antigen MZ2-E, MGC9326) 2ug　M1750-20

特徴

• Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on mormal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
• Recombinant Human MAGE1 produced in E. coli is a non-glycosylated, polypeptide chain containing 200aa and having a molecular mass of 22.7kD.
• Characterization:MAGE-1 antibody reactive.
• Storage and Stability:May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.