85-1434-91　Hepatitis C Virus Core, Nucleocapsid, Genotype 3b, Recombinant (HCV) 100ug　H1920-18K

特徴

• The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition,HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
• The protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-119.
• Applications:Suitable for use in ELISA and Western Blot adn is excellent for detection of HCV with minimal specificity problems. Other applications not tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Specificity:Immunoreactive with seum of HCV-infected individuals
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.