85-1434-69　［取扱停止］Hepatitis C Virus Core, Nucleocapsid p22, Recombinant (HCV) (FITC) 100ug　H1920-17Y

特徴

• The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is co-translationally inserted into the membrane of the endoplasmic reticulum (ER). Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathway. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
• Product Description:The E.coli-derived recombinant protein contains the HCV core nucleocapsid immunodominant region, amino acids 2-192. This Fluorescein-labeled protein is fused with beta-galactosidase (114 kDa) at the N-terminus.
• Specificity:Immunoreactive with sera of HCV-infected individuals
• Applications:Recombinant HCV Core Antigen may be used in ELISA and Western Blot. Excellent for detection of HCV with minimal specificity problems.
• Storage and Stability:Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.