85-1433-87　［取扱停止］Factor VIIa, Recombinant, Human 10ug　F0016-14R

特徴

• Human coagulation factor VII is a single chain protease that circulates in the blood as a weakly active zymogen at concentrations of approximately 10nmol/L. When converted to the active 2 chain form (VIIa), it is a powerful initiator of hemostasis. Recombinant Factor VIIa is a unique hemostatic agent with potential for broad-spectrum applications in bleeding patients with congenital and acquired bleeding abnormalities. At present, recombinant Factor VIIa is only approved for the treatment of hemophilia A and B patients who have acquired antibodies to Factors VIII and IX.
• Recombinant Human Factor VIIa produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.
• Biological Activity:Recombinant Factor-VIIa is fully biologically active when compared to standard. The potency was found to be 50,000 Units/mg.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.