85-1433-69　［取扱停止］Endostatin, Recombinant, Human, active 250ug　E2900-09

特徴

• Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin familyEndostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells
• Recombinant Human Endostatin is a single, glycosylated, polypeptide having a total molecular mass of 20,000D. C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell prolifiration.
• Sequence:In total agreement with the expected amino acid composition of native human Endostatin.
• Biological Activity:Human Endostatin is fully biologically active when compared to standards. The activity calculated by ECE migration inhibition was found to be 16,000IU/mg.
• Storage and Stability:May be stored at 4°C before opening. DO NOT FREEZE! Stable for 6 months after receipt.. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.