85-1432-83　［取扱停止］Actinomycin D (Dactinomycin) 5mg　CAS No:50-76-0　A0850

特徴

• Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Antibiotic. Antitumor compound. Cytotoxic. Apoptosis inducer. RNA synthesis inhibitor. DNA intercalating agent. Mcl-1 expression inhibitor. p53 pathway activator.
• Source:Streptomyces sp.
• Synonyms:Streptomyces antibioticus; 2-Amino-(N,N)-1-bis(hexadecahydro-6­,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentao­xo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-ox­o-3H-phenoxazine-1,9-dicarboxamide; Dactinomycin, Actinomycin IV, Actinomycin C1; Actactinomycin A IV; Actinomycin 7; Dilactone Actinomycindioic D Acid; Lyovac Cosmegen; Cosmogen; Meractinomycin
• Molecular Formula:C62H86N12O16
• Molecular Weight:1255.43
• Appearance:Orange to bright red crystaline powder
• Purity:≥98%
• Solublility (DMSO, 50mg/ml):Clear orange solution
• Specific Rotation:-293°~-329°
• Melting Point:243~248ºC (lit)
• Crystallinity:Conforms
• Loss on Drying:≤5%
• DNase:None Detected
• RNase:None Detected
• Protease:None Detected
• Endotoxin:≤0.5EU/mg
• Total Impurities (HPLC):≤2%
• Storage and Stability:May be stored at 4°C. Stable for 12 months after receipt.