Human parathyroid hormone (hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium back resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts.
Recombinant protein corresponding to aa1-84 from human parathyroid hormone, overexpressed in E. coli.
Molecular Weight:~9.55kD (85aa) confirmed by MALDI-TOF
AA Sequence:MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLTKAKSQ
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：500ug
Source Antigen：Recombinant, E. coli
Grade：Purified
Purity：≥90% by SDS PAGE; Purified by conventional column chromatography techniques. Endotoxin: <1EU/1ug (LAL)
Form：Supplied as a liquid in PBS, pH 7.4, 2mM EDTA.
