Present mainly in the mitochondrial compartment of peripheral tissues, PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBR-S is also expressed in the same tissues, but at a level about ten times that of PBR.
Species: Homo sapiens
Source: E. coli
Primary Sequence (aa): 102
Domain (aa): Full-length
Tag/Fusion Partner: T7 Tag
Applications: Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested.
Quality Control: SDS-PAGE
Storage and Stability:May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Important note: This recombinant enzyme has NOT been tested with regard to biological activity.
仕様
Size：50ug
Source Antigen：Recombinant, E. coli
Grade：Highly Purified
Purity：~95%
Form：Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100, 10mM DTT, 0.002% sodium azide.
