Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).
Physical Appearance:Colorless frozen solution.
Solubility: 2-5mg/ml
Absorbance (280nm, E0.1% 1.9): 2.2
Storage and Stability:Store frozen at -70°C – stable for ≥1 year.
仕様
Size：500ug
Grade：Highly Purified
Purity：>98% pure by SDS-PAGE 98 (+/-) 2% active by uPA titration.
