85-1409-06　Plasminogen Activator Inhibitor Type 1 mutant, vitronectin binding (PAI-1) 500ug　P4256-29N

特徴

• Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).
• Physical Appearance:Colorless frozen solution
• Solubility:>2mg/ml and <5mg/ml
• Buffer Composition:0.05M sodium phosphate; 0.1M sodium chloride; 1mM EDTA; pH 6.6
• Purity:>98% pure by SDS PAGE 95 (+/-) 5% active by uPA titration.
• Absorbance (280nm): 3.6 E0.1% = 1.0Concentration = 3.6mg/mlActive Concentration = 3.4mg/ml
• Kinetic Data:Second order rate constants for inhibition of:UPA = 6.3 X 106 M^-1s^-1tPA = 5.7 X 106 M^-1s^-1
• Storage and Stability:Store frozen at -70°C – stability >1 year.