Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).
Solubility:>2mg/ml and <5mg/ml
Kinetic Data:Second order rate constants for inhibition of:uPA = 6.3 X 10e6 M^-1s^-1 tPA = 5.7 X 10e6 M^-1s^-1
Storage and Stability:May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
仕様
Size：500ug
Grade：Highly Purified
Purity：≥98% by SDS PAGE 95 ± 5% active by uPA titration
Form：Supplied as a liquid in 0.05M sodium phosphate; 0.1M sodium chloride; 1mM EDTA; pH 6.6. Labeled with Biotin.
