Ecotin is a serine protease inhibitor that is found in the periplasm of Escherichia coli. It has a very broad range of inhibition including the pancreatic serine proteases trypsin and chymotrypsin, human leukocyte and porcine elastase and rat mast cell chymase. Ecotin is regarded as a potent, tight-binding, reversible inhibitor of Factor Xa. Ecotin does not inhibit the human plasma proteases thrombin, tissue factor-factor VIIa, Factor XIa, Protein C, plasmin or tPA.
Kinetic Data:1:1 inhibition of trypsin
Storage and Stability:For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 12 months after receipt.
