85-1405-63　［取扱停止］Bradykinin Receptor Type B1, Rat, Control Peptide (BK-1 Receptor, BRADYB1, BKR1, BKB1R, B1R, B1BKR, BDKRB1) 5x1mg　B2675-90A

特徴

• Bradykinin is a nine-amino-acid vasoactive peptide which elicits numerous physiologic responses such as vasodilation, smooth muscle spasm and pain. Bradykinin is one of a family of such peptides called the kinins. These kinins are generated by proteolysis of high-molecular-weight precursors called kininogens upon activation by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are brought about through their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes; B1 and B2, both of which appear to be coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven-helix G-protein-coupled receptors. Bradykinin has relatively low affinity for B1 receptors, interacting primarily with the B2 receptor through which several second messenger systems are stimulated, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.
• Applications: Suitable for use in ELISA. Other applications not tested.
• Synthetic (linear) peptide to Bradykinin Receptor Type B1. Sequence is WWWQQRQRQQRL-Cysteine. This is the control peptide for anti-Bradykinin Receptor Type B1 B2675-90.
• Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
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