A 18 mer peptide locating near the amino terminus of Presenilin-2 .
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. A number of genes have been linked in the initiation and development of AD. An early onset of familial AD has been linked to some 30 mutations in two related genes, Presenilins-1 (PS-1 on chromosome 14; 467 aa) and Presenilins-2 (PS-2 on chromosome 1; 448 aa). PS-1/2 have been colocalized in subcellular sites involved in cell cycle regulation and mitosis (the nuclear membrane, interphase kinetochore, and centrosome).
Applications:ELISA: 1:10K-1:100K using 50-100ng of control peptide/well.
仕様
Size：100ug
Source Antigen：Human synthetic peptide
Grade：Highly Purified
Purity：Chromatographically purified
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium merthiolate.
Specificity：Human peptide has 100% homology to human, mouse and rat Presenilin-2
