Melanocortins are regulatory peptides formed by post-translational processing of pro-opiomelanocortin. Melanocortin peptides have been suggested to perform a variety of physiological roles ranging from control of behavior, memory, neurotrophic properties, antipyretic and modulation of immune system, etc. Their binding sites have been found distributed in tissues ranging from lachrymal and submandibular glands, pancreas, adipose tissue, bladder, duodenum, spleen, brain, gonadal tissues and malignant melanoma tumors. Five melanocortin receptors have been characterized to date. These include melanocyte-stimulating hormone receptor (MSH or MC1-R), corticoaderenal-specific ACTH receptor (MC2-R), melacortin-3 (MC3-R), melanocortin-4 (MC4-R) and melanocortin-5 receptor (MC5-R). MC3-R and MC4-R are distributed in brain whereas MC5-R has a broad distribution.
Rat Melanocortin receptor (MC4-R) is a 332 amino acid transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for MSH (a,b,g) and ACTH. It is found in brain, placenta, and gut tissues. Anti-Rat MC4-R antibodies were raised against 18 aa peptide mapping near the N-terminal, 1st extracellular domain of rat MC4-R.
仕様
Size：100ug
Source Antigen：Rat synthetic peptide
Grade：Highly Purified
Purity：Highly purified
Form：1mg/ml soln. in PBS, pH 7.4 and 0.02% sodium azide/Merthiolate
Specificity：88% (16/18 aa) homologous with human MC4-R. No significant sequence homology of mCR41 is seen with other melanocortin receptors
