A 17 aa peptide within the cytoplasmic, C-terminus of human H4R .
Histamine, one of the most important mediators of allergy and inflammation, is a chemical messenger and aminergic neurotransmitters. It plays an important role in a multitude of physiological processes in central and peripheral tissues. Histamine is synthesized in a restricted population of neurons located in the tuberomammillary nucleus of the posterior hypothalamus implicated in many brain functions (e.g. sleep/wakefulness, hormonal secretion, cardiovascular control, thermoregulation, food intake, and memory formation). In peripheral tissues histamine is stored in mast cells, basophils, enterochromaffin cells. Histamine release leads to various well-known symptoms of allergic conditions in the skin and the airway system. Histamine effects are mediated by four pharmacologically distinct receptors, the H1R, H2R , H3R and H4R receptors, which are all members of the G-protein coupled receptor (GPCR) family. Histamine receptors display 7 TM domains, an extracellular N-terminus, and a cytoplasmic C-terminus of variable length.
Most recently, a novel orphan G-protein coupled receptor, named H4R (GPRv53, human 390 aa) has been cloned and characterized. It is most closely related to H3R (~37% homology). Unlike H3R, H4R has a distinct tissue distribution and it is localized in the peripheral blood leukocytes, spleen, thymus and colon. Mammalian cells expressing H4R were demonstrated to bind and respond to histamine in a concentration-dependent manner. In functional assays, an H3 receptor agonist, R-(a)-methylhistamine, but also a H3 receptor antagonist, clobenpropit, and a neuroleptic, clozapine, activated H4R-expressing cells.
仕様
Size：100ug
Source Antigen：Human synthetic peptide
Grade：Highly Purified
Purity：Highly purified
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：The human peptide sequence is unique to human H4R
