An 18 aa peptide within the extracellular, N-terminus of human H2R .
Histamine, one of the most important mediators of allergy and inflammation, is a chemical messenger and aminergic neurotransmitters. It plays an important role in a multitude of physiological processes in central and peripheral tissues. Histamine is synthesized in a restricted population of neurons located in the tuberomammillary nucleus of the posterior hypothalamus implicated in many brain functions (e.g. sleep/wakefulness, hormonal secretion, cardiovascular control, thermoregulation, food intake, and memory formation). In peripheral tissues histamine is stored in mast cells, basophils, enterochromaffin cells. Histamine release leads to various well-known symptoms of allergic conditions in the skin and the airway system. Histamine effects are mediated by four pharmacologically distinct receptors, the H1R, H2R , H3R and H4R receptors, which are all members of the G-protein coupled receptor (GPCR) family. Histamine receptors display 7 TM domains, an extracellular N-terminus, and a cytoplasmic C-terminus of variable length.
The H2R (mouse/rat 358 aa; human 359 aa chromosome 5) causes cAMP accumulation in the gastric cells, cardiac tissues, smooth muscle cells and immune cells. H2R agonists have been proven to be effective for acid peptic disorders of the GI tract. H2R is moderately expressed in the brain. H2 receptor agonist, dimaprit, is a relatively selective H2 receptor agonist with minimal H1R receptor agonism. Recently, amthamine (2-amino-5-(2-aminoethyl)-4-methylthiazole), a rigid dimaprit analog, combines a high H2R receptor selectivity. Interestingly, mutations in H2R has been linked to schizophrenia.
仕様
Size：100ug
Source Antigen：Human synthetic peptide
Grade：Highly Purified
Purity：Highly purified
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：The human peptide sequence is 100% conserved in fish, 66% in canine, mouse and rat, H2R
