85-1400-83　GABA Receptor Associated Protein, Human (GABARAP) Control Peptide 100ug　G1015-24D

特徴

• A 19aa Peptide sequence near the N-terminus of human GABARAP (2) was selected for antibody production. The peptide was coupled to KLH.
• GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). A family of GABA-A receptors subtypes exists, which are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta, and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627 aa) are characterized by the presence of a large cytoplasmic domain that may be involved in anchoring the receptor to the cytoskeleton. Most recently, a new cellular protein, termed GABA A receptor associated protein (GABARAP), has bee shown to interact with gamma 2 subunit of GAA. GABARAP has similarity with light chain-3 microtubule associated protein 1A and 1B. N-terminus of GABARAP also possess a tubulin-binding motif. Therefore, a possible interaction of GAA, GABARAP, and tubulin suggest for the targeting and clustering of GAA. GABARAP is found in brain and most other tissues.