The inhibitors of apoptosis proteins (IAPs) are a widely expressed gene family of apoptotic inhibitors. Recently, a new human gene encoding a structurally and unique IAP designated Survivin has been identified. Survivin (human 142 aa, ~16.5kD) is highly expressed in less-differentiated embryonic cells or rapidly dividing tumor cell but not in fully differentiated adult tissues. Interestingly, Survivin coding strand has significant sequence homology with Effector cell Protease Receptor-1 (EPR-1) suggesting a potential for functional interaction between these two proteins.
Factor Xa plays a critical role in the coagulation process by catalyzing the activation of prothrombin to thrombin. It acts on leukocytes, endothelium and smooth muscle cells triggering complex pathways of intracellular signaling. Factor Xa binds to EPR-1. The full length EPR-1 predicts a protein of 337 aa (~65kD de-glycosylated form). EPR-1 is expressed in vascular endothelial cells and smooth muscle cells. Survivin and EPR-1 are encoded by structurally and topographically distinct messages from potentially originating from gene cluster at chromosome 17q25. Overexpression of EPR-1 increased apoptosis and inhibited growth of transformed cells. The importance of the Survivin-EPR-1 interaction remains to be elucidated.
仕様
Size：100ug
Source Antigen：Human synthetic peptide
Grade：Highly Purified
Purity：Highly purified
Form：Supplied as a liquid in PBS, pH 7.2
Specificity：No significant sequence homology with Survivin. Antibody crossreactivity with EPR-1 from other species is not known
