A 17aa Peptide sequence near the C-terminus of rat CLC-K1.
Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential stabilization, signal transduction, and transepithelial transport. Mutations in CIC genes have been linked with several human diseases including myotonias (Thomsen's disease), cystic fibrosis, Bartters syndrome type III, Dent's disease, and X-linked recessive nephrolithiasis. In mammals, CLC proteins form a superfamily of at least 9 different genes (CLC1-7 also known as CLCN1-7 and CLK1-2 or CLCKa and CLCKb). Additional forms of these proteins are obtained by alternative splicing. All CLC proteins (~700-1000 aa) are predicted to contain 10 (possibly 12) transmembrane domains.Except CLC-1 and CLC-K1/K2 that are specific for kidney, most other CLC are widely distributed in various tissues.
Rat CLC-K1 is 687 aa membrane protein (human 687 aa) (1). CLC-K1 is ~84% identical with CLC-K2 (2). CLC-K1 is specific for kidney (cortical thick ascending limb and the distal convoluted tubule with minor expression in the S3 segment of the proximal tubule and the cortical collecting tubule). It may play a role in urine concentrating mechanism.
仕様
Size：100ug
Source Antigen：Rat synthetic peptide
Grade：Highly Purified
Purity：Highly purified
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：93% conserved in human CLC-K1 or CLC-Ka. It also has high homology with rat CLC-K2 and 81% with human CLC-K2. Anti-rat CLCK11 should crossreact with both CLC-K1 and CLC-K2. No significant sequence homology is detected with other CLCs or other proteins
