85-1399-68　Calsarcin 1, Mouse, Control Peptide (Myozenin 2, Calcineurin Binding Protein) 100ug　C1036-04B

特徴

• A 17-aa peptide sequence from the C-terminus of mouse Calsarcins-1.
• Calcineurin is a Ca/calmodulin-dependent serine-threonine phosphatase that plays an important role in transducing Ca-dependent signals in a variety of cell types. Calcineurin has also been shown to have a profound influence on the properties of striated muscle cells, including cardiac muscle. A novel family of striated muscle-specific calcineurin-interacting proteins called calsarcins or myozenins has been identified that interact and colocalize with the Z-disc protein alpha-actinin. Two isoform of calsarcins, Calsarcin-1 and Calsarcin-2, with specific expression pattern have been identified in human, rat and mouse. Calsarcins tether calcineurin to the sarcomere of cardiac and skeletal muscle. Besides calcineurin and ?-actinin, calsarcins interact with other Z-disc proteins ?-filamin, telethonin and TCAP. Because calcineurin responds to sustained, low amplitude calcium signals, calsarcins may serve to localize calcineurin in the vicinity of unique intracellular pool, where it can interact with specific upstream activators or downstream substrates. Therefore, calsarcins may play an important role in modulating the function and substrate specificity of calcineurin in striated muscle cells.
• Calsarcin-1 (CALS-1), also known as Myozenin-2 or MYOZ2, is a ~32kD protein (human/mouse 264-aa, ~88% identity). Amino acids 217-240 of calsarcin-1 are necessary for its interaction with a-actinin-2 in the Z-disc of sarcomeric muscle fibers. It is expressed, throughout the development-cycle, in all striated muscle tissues. However, CALS-1 expression is localized in slow-twitch fibers (soleus and plantaris), which depends on chronic motor neuron stimulation that results in sustained cellular calcium.