Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Recombinant protein corresponding to human Matrix Metalloproteinase 7, expressed in E. coli.
Specific Activity:~3100U/mg
Unit Definition:One unit of enzyme activity is defined as the digestion of 1ug of Azocoll/min. at pH 7.5 and 37ºC in the presence of 0.5mM p-aminophenylmercuric acetate.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：10ug
Source Antigen：Recombinant, E. coli
Grade：Purified
Purity：≥70% when analyzed by SDS-PAGE followed by staining with CBB R-250.
Form：Supplied as a liquid in 25mM Tris-HCl, pH 7.5, 5mM CaCl2, 0.15M sodium chloride, 0.01% Brij35 0.02%
