Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2
Geldanamycin acts by binding to the 90kD heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localization of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1alpha, survivin and telomerase hTERT.
Related to: Antibiotic TAN 420C, Antibiotic TAN 420E, Herbimycin A, Herbimycin B.
Appearance:Supplied as a yellow, lyophilized powder.
Storage and Stability: Store at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light.
