Heterogeneous nuclear ribonucleoproteins (hnRNP) bind to nascent RNA polymerase II transcripts and are involved in transcript-specific packaging as well as alternative splicing of pre-mRNAs. hnRNPs also appear to influence mRNA metabolism and transport. In vivo, the M proteins bind to mRNA, and in vitro they bind avidly to poly(G) and poly(U) homopolymers. Four different isoforms of hnRNP are produced by alternative splicing: M1, M2, M3, and M4. Ongoing studies have theorized that hnRNPs may cause certain genetic diseases such as myotonic dystrophy, which is the most common form of adult muscular dystrophy. The identification of hnRNPs may therefore be important to determining the cause and cure for genetic diseases.
Source: Calf and rabbit thymus. All bovine materials are of US origin.
One unit of activity is the amount of antigen that will generate an absorbance of 1.2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditions/protocols.
Applications: Recommended for use in standard solid phase immunoassays.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1000U
Source Antigen：Calf thymus, and rabbit thymus.
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography. Purification is verified by SDS PAGE. Other antigens are not detected with ELISA assays.
Form：Supplied as a liquid in 0.01M Tris, 0.5M sodium chloride, 0.02% sodium azide.
