Cathepsins are localized primarily in lysosomes or endosomes, but translocated to the cytosol during apoptosis. The translocation allows these proteases to interact with caspases or other apoptosis signaling mechanisms. Studies show that cathepsins cleave certain caspases, and caspase inhibitors can inhibit cathepsin activity in vitro.
Activity:≥ 200 Units/mg protein using Z-Arg-Arg-beta-NA as a substrate. One unit is defined as the amount of enzyme that hydrolyzes one umole of 2-naphtylamine per minute at 40°C, pH 6.0.
Storage and Stability:For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
仕様
Size：25ug
Source Antigen：Human liver
Grade：Highly Purified
Purity：~95% (SDS-PAGE)
Form：Supplied as a liquid in 50mM sodium acetate, pH 5.0, 1mM EDTA.
