A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Synthetic peptide (CPDLVCYTDYLQT) corresponding to amino acids 20 to 32 of human IL-21R precursor (1)
仕様
Size：50ug
Grade：Molecular Biology Grade
Form：Supplied as a liquid at 200ug/ml in PBS, pH7.2 (10mM sodium phosphate monobasic, 10mM sodium phosphate dibasic, 130mM sodium chloride), 0.1% bovine serum albumin, 0.02% sodium azide.
Specificity：Human Interleukin-21R. An approximately 60kD band can be detected.
