Peptide corresponding to amino acid 546 to 564 of human IRAK2 (1).
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor 1 (IL-1R1) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation (2,3). Members in the IRAK/Pelle family play a central role in IL-1R- and TLR-mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
