85-1370-16　TWEAK, Recombinant, Human (TNF-related Weak Inducer of Apoptosis, APO3 Ligand, APO3/DR3 Ligand, APO3L, CD255, DR3LG, FN14, Tumor Necrosis Factor Ligand Superfamily Member 12, TNFSF12, UNQ181/PRO207) 25ug　T9185

特徴

• Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many members of the TNF family, was able to induce interleukin-8 synthesis in a number of cell lines. Recombinant Human TWEAK is a 17.0kD protein, comprising the TNF-like extracellular domain of TWEAK.
• Biological Activity:The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC (peripheral blood mononuclear cells) is less than 10ng/ml. TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN-y. The ED50 for this effect if between 30-45ng/ml.
• AA Sequence:MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Country of Origin:USA