Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo.
Chemical Name: N-benzyl-3,4-dihydroxybenzylidenecyanoacetamide
Chemical Family: Aromatic nitrile
Solubility: Soluble in DMSO
Melting Point: 215-216.5°C
Storage (unopened): Store at or below 4°C in the dark.
