85-1367-71　Lovastatin (Mevinolin) 50mg　CAS No:75330-75-5　L3450

特徴

• Cancer cell line apoptotic inducer via HMG-CoA reductase mechanism. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).
• Synonyms:Mevinolin; 6a-Methylcompactin; Monakolin K; MK-803, 6-alpha-Methylcompactin; BRN 3631989
• Source:Aspergillus sp.
• Molecular Formula:C24H36O5
• Molecular Weight:404.5
• Purity:≥98.5%
• Appearance:White crystalline powder
• Solubility:Soluble in DMSO and ethanol
• Loss on Drying:≤0.1%
• Heavy Metals:≤0.002%
• Specific Rotation:+324°-338°
• Residue on Ignition:≤0.2%
• Indentification (Infrared, UV):Conforms to reference
• Exceeds USP Specifications