85-1363-69　Colchicine ((-)-Colchicine) 5g　CAS No:64-86-8　C7507

特徴

• Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines.
• Synonyms:(-)-Colchicine; NSC 757; EINECS 200-598-5, N-​[(7S)-​1,​2,​3,​10-​ tetramethoxy-​9-​oxo-​5,​6,​7,​9-​tetrahydrobenzo​[a]​heptalen-​ 7-​yl]​acetamide
• Source:Colchicum autumnale
• Molecular Weight:399.4
• Molecular Formula:C22H25NO6
• Appearance:Pale yellow to green crystalline powder
• Purity (HPLC):Content of Colchicine: 94-101% (HPLC)
Chromatographic Purity: ≥95% (HPLC)
• Melting Point:155-157°C
• Optical Rotation:[a]D20 = -240 to -250º (C=1 in EtOH)
• Water (KF):≤2%
• E. coli, Salmonella, S. aureus:Negative
• Yeast and Mold:≤100cfu/g
• Microbial Count:≤1000cfu/g (TPC)
• Related Substances:Total Impurity: ≤5%
• Residual Solvents:Limit of Colchicine: CompliesLimit of Ethylacetate: ≤8%Chloroform: ≤100ppmMethylene chloride: ≤ 600ppmMethanol: ≤ 3000ppmHexane: ≤290 ppm
• Solubility:100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF
• Storage and Stability:Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.