85-1355-37　［受注停止］Protein Kinase Inhibitor H-89 (PKI, N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) (N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) 10mg　CAS No:127243-85-0　P9104-35

特徴

• Protein Kinase InhibitorsThe newly synthesized isoquinolinesulfonamide derivatives KN–62, KN–04, H–89, H–88, H–85, CKI–7, and CKI–8, as well as methoxybenzenesulfonamide derivatives KN–93 and KN–92 are protein kinase inhibitors which exert their strong inhibitory effects by directly binding to the protein kinase molecules. KN–62 is a selective and potent inhibitor of Ca++/calmodulin–dependent protein kinase II (Ca++/CaM Kinase II). The inhibition of KN–62 against Ca++/CaM Kinase II is more significant than the other protein kinases and is effective in lower concentrations.
• KN–04, which closely resembles KN–62 in its chemical structure, exhibits a weak protein kinase inhibition and is useful as a control for KN–62.
• KN–62 and KN–04 are useful tools for elucidation of the function of the enzyme in relation to cellular responses.
• H–89 and H–88 have a potent and selective inhibitory effect against cyclic AMP–dependent protein kinase (Protein Kinase A).
• H–89 is most powerful among various protein kinase A inhibitors.
• H–85 closely resembles H–89 in its chemical structure. It is not specific to Protein Kinase A and has similar inhibitory effects on other kinases ; hence this compound can be used as a negative control of H–89.
• CKI–7 has a potent inhibitory effect against casein kinase I and a much weaker effect on casein kinase II as well as other protein kinases.
• CKI–8, a derivative of CKI–7, is used as an affinity ligand to purify casein kinase I. These newly synthesized compounds should serve as useful tools for elucidating the biological significance of casein kinase I –mediated reactions.
• KN–93, a modified type of KN–62, is also a potent and specific inhibitor of Ca++/CaM Kinase II and its solubility in buffered solution is superior to KN–62.
• KN–92, which closely resembles KN–93 in its chemical structure, exhibits no inhibitory effect to Ca++/CaM Kinase II and is used as a control for KN- 93.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with DMSO for stock solution. Store at 4°C. Stock product is stable for 6 months at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.