背景：Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry.
Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein.
The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch.
Nucleocapsid protein is the most abundant protein of coronavirus.
During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid.
Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways.
Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
遺伝子構造：A DNA sequence encoding the SARS-CoV-2 Nucleocapsid （with mutations P13L, ERS31-33 deletion, R203K, G204R） （Met1-Ala419） was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：2019-nCoV coronavirus NP Protein; SARS-Cov-2 np Protein; Omicron Nucleoprotein Protein
分子量：46.31 kDa
組成：Lyophilized from sterile 50mM PB, 500mM NaCl, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
