84-9376-68　Recombinant SARS-CoV-2 Spike RBD（E484K）（His Tag） 100ug　PKSV030366

特徴

• 背景：The spike （S） glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.
• Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid.
• The spike is essential for both host specificity and viral infectivity.
• The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.
• The spike （S） glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
• It's been reported that SARS-CoV-2 （COVID-19 coronavirus, 2019-nCoV） can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
• The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
• S1 mainly contains a receptor binding domain （RBD）, which is responsible for recognizing the cell surface receptor.
• S2 contains basic elements needed for the membrane fusion.
• The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
• The main functions for the Spike protein are summarized as： Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain （RBD）, leading to a higher mortality rate.