特徴
- 背景：The protein encoded by this gene is a member of the platelet-derived growth factor family.
- The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.
- This gene product can exist either as a homodimer （PDGF-BB） or as a heterodimer with the platelet-derived growth factor alpha polypeptide （PDGF-AB）, where the dimers are connected by disulfide bonds.
- Mutations in this gene are associated with meningioma.
- Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.
- Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
仕様
- サイズ：20ug
- 種由来：Rat
- 発現宿主：E.coli
- 純度：＞85 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションNo.：Q05028-1
- アミノ酸配列：Ser74-Thr182
- 遺伝子構造：A DNA sequence encoding the Rat PDGF-B （Q05028-1） （Ser74-Thr182） was expressed with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：Becaplermin;PDGF 2;PDGF B chain;PDGF subunit B;PDGF-2;PDGF2;Pdgfb;PDGFB;Platelet derived growth factor 2;Platelet-derived growth factor B chain;Platelet-derived growth factor beta polypeptide;Platelet-derived growth factor subunit B;Proto-oncogene c-Sis;SIS;SSV
- 分子量：12.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4., 5％ trehalose, 5％ mannitol, 0.01％ tween-80.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9374-87
Recombinant Rat PDGF-B Protein （His Tag） 20ug
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84-9354-67
Recombinant Rat PDGF-B Protein （His Tag） 100ug
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84-9354-66
Recombinant Rat PDGF-B Protein （His Tag） 20ug
|
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