84-9374-72　Recombinant Human ACE2 Protein （His Tag） 100ug　PKSR030508

特徴

• 背景：Angiotensin-converting enzyme 2 （ACE2）, a first homolog of ACE, regulates the renin angiotensin system （RAS） by counterbalancing ACE activity.
• Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems.
• ACE2 also has an important role in blood pressure control.
• This enzyme, an homolog of ACE, hydrolyzes angiotensin （Ang） I to produce Ang-（1-9）, which is subsequently converted into Ang-（1-7） by a neutral endopeptidase and ACE.
• ACE2 releases Ang-（1-7） more efficiently than its catalysis of Ang-（1-9） by cleavage of Pro（7）-Phe（8） bound in Ang II.
• Thus, the major biologically active product of ACE2 is Ang-（1-7）, which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system.
• A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus.
• In the acute respiratory distress syndrome （ARDS）, ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS.
• Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome （SARS） pathogenesis.
• Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder.
• This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.